Article
Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD.
Disease models & mechanisms - 1 Dec 2014
Wang Qi, Xiao Bing, Cui Shuqin, Song Hailong, Qian Yanjing, Dong Lin, An Haiting, Cui Yanqiu, Zhang Wenjing, He Yi, Zhang Jianliang, Yang Jian, Zhang Feilong, Hu Guanzheng, Gong Xiaoli, Yan Zhen, Zheng Yan, Wang Xiaomin
Abstract excerpt
The complex pathogenesis of Alzheimer's disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress. Effective therapeutic strategies for AD are still urgently needed. Triptolide is the major active compound extracted from Tripterygium wilfordii Hook.f., a traditional Chinese medicinal herb that is commonly used to treat inflammatory...
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