Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.

Scientific reports - 6 Apr 2017

Li Jian-Guo, Barrero Carlos, Merali Salim, Praticò Domenico

Abstract excerpt

Environmental and genetic risk factors are implicated in the pathogenesis of Alzheimer's disease (AD). However, how they interact and influence its pathogenesis remains to be investigated. High level of homocysteine (Hcy) is an AD risk factor and associates with an up-regulation of the ALOX5 gene. In the current paper we investigated whether this activation is responsible for the Hcy effect on the AD phenotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folic Acid
Share to Folic Acid Deficiency
Share to Homocysteine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxyurea

Share to Lipoxygenase

Share to Synapses

Share to tau Proteins

Share to Vitamin B Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 28383037
DOI: 10.1038/srep46002
PMCID: PMC5382538

Genes

ALOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.PMID 28383037Read ↗

Homocysteine modulates 5-lipoxygenase expression level via DNA methylationSemantic proximity Read ↗

Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.Semantic proximity Read ↗

Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA MethylationSemantic proximity Read ↗

Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity.Semantic proximity Read ↗

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.Semantic proximity Read ↗

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimerâ€™s disease phenotypeSemantic proximity Read ↗

Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.Semantic proximity Read ↗

The 'golden age' of DNA methylation in neurodegenerative diseases.Semantic proximity Read ↗

Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target?Semantic proximity Read ↗

One-Carbon Metabolism and Alzheimers Disease: Focus on EpigeneticsSemantic proximity Read ↗

One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.