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Article

Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.

Molecular psychiatry - 1 Nov 2019

Di Meco Antonio, Li Jian-Guo, Barrero Carlos, Merali Salim, Praticò Domenico

Abstract excerpt

A high circulating level of homocysteine (Hcy), also known as hyperhomocysteinemia, is a risk factor for Alzheimer's disease (AD). Previous studies show that elevated Hcy promotes brain amyloidosis and behavioral deficits in mouse models of AD. However, whether it directly modulates the development of tau neuropathology independently of amyloid beta in vivo is unknown. Herein, we investigate the effect of...

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Identifiers

PMID: 29728702
DOI: 10.1038/s41380-018-0062-0
PMCID: PMC6215750

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