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Article

Mechanistic implications of enhanced editing by a HyperTRIBE RNA-binding protein.

RNA (New York, N.Y.) - 1 Feb 2018

Xu Weijin, Rahman Reazur, Rosbash Michael

Abstract excerpt

We previously developed TRIBE, a method for the identification of cell-specific RNA-binding protein targets. TRIBE expresses an RBP of interest fused to the catalytic domain (cd) of the RNA-editing enzyme ADAR and performs adenosine-to-inosine editing on RNA targets of the RBP. However, target identification is limited by the low editing efficiency of the ADARcd. Here we describe HyperTRIBE, which carries a...

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Share to Adenosine
Share to Adenosine Deaminase
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterogeneous-Nuclear Ribonucleoproteins

Share to Inosine

Share to RNA-Binding Proteins

Share to RNA Editing

Share to Sequence Analysis, RNA

Source

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Identifiers

PMID: 29127211
DOI: 10.1261/rna.064691.117
PMCID: PMC5769745

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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