Article
Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli.
International journal of antimicrobial agents - 1 Mar 2018
Khan David D, Lagerbäck Pernilla, Malmberg Christer, Kristoffersson Anders N, Wistrand-Yuen Erik, Sha Cao, Cars Otto, Andersson Dan I, Hughes Diarmaid, Nielsen Elisabet I, Friberg Lena E
Abstract excerpt
Predicting competition between antibiotic-susceptible wild-type (WT) and less susceptible mutant (MT) bacteria is valuable for understanding how drug concentrations influence the emergence of resistance. Pharmacokinetic/pharmacodynamic (PK/PD) models predicting the rate and extent of takeover of resistant bacteria during different antibiotic pressures can thus be a valuable tool in improving treatment regimens....
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