Article
Bacterial resistance studies using in vitro dynamic models: the predictive power of the mutant prevention and minimum inhibitory antibiotic concentrations.
Antimicrobial agents and chemotherapy - 1 Oct 2013
Firsov Alexander A, Strukova Elena N, Shlykova Darya S, Portnoy Yury A, Kozyreva Varvara K, Edelstein Mikhail V, Dovzhenko Svetlana A, Kobrin Mikhail B, Zinner Stephen H
Abstract excerpt
In light of the concept of the mutant selection window, i.e., the range between the MIC and the mutant prevention concentration (MPC), MPC-related pharmacokinetic indices should be more predictive of bacterial resistance than the respective MIC-related indices. However, experimental evidence of this hypothesis remains limited and contradictory. To examine the predictive power of the ratios of the area under the...
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