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Article

Suppression of ciprofloxacin-induced resistant Pseudomonas aeruginosa in a dynamic kill curve system.

International journal of antimicrobial agents - 1 Jun 2011

Wu Benjamin M, Sabarinath Sreedharan N, Rand Kenneth, Johnson Judith, Derendorf Hartmut

Abstract excerpt

Current dosing approaches for treating microbial infections ignore resistant subpopulations. A clinical isolate of Pseudomonas aeruginosa was cultured in a dynamic in vitro kill curve system designed to simulate the half-lives of drugs in order to evaluate the drug-microbial response relationship. The first dose of ciprofloxacin (CIP) uses a concentration equivalent to the unbound fraction of a 200mg clinical...

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Identifiers

PMID: 21497064
DOI: 10.1016/j.ijantimicag.2011.01.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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