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Article

Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration.

The Journal of antimicrobial chemotherapy - 1 Jun 2006

Olofsson Sara K, Marcusson Linda L, Komp Lindgren Patricia, Hughes Diarmaid, Cars Otto

Abstract excerpt

OBJECTIVES: To evaluate the mutant prevention concentrations (MPCs) of ciprofloxacin for two susceptible and one first-step gyrA resistant mutant Escherichia coli strains in an in vitro kinetic model and to identify the pharmacodynamic index that best predicts prevention of resistance emergence. METHODS: An in vitro kinetic model was used to measure MPC with static antibiotic concentrations and to test different...

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Identifiers

PMID: 16624874
DOI: 10.1093/jac/dkl135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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