Article
Bacterial antibiotic resistance studies using in vitro dynamic models: Population analysis vs. susceptibility testing as endpoints of mutant enrichment.
International journal of antimicrobial agents - 1 Sept 2015
Firsov Alexander A, Strukova Elena N, Portnoy Yury A, Shlykova Darya S, Zinner Stephen H
Abstract excerpt
Emergence of bacterial antibiotic resistance is usually characterised either by population analysis or susceptibility testing. To compare these endpoints in their ability to demonstrate clear relationships with the ratio of 24-h area under the concentration-time curve (AUC24) to the minimum inhibitory concentration (MIC), enrichment of ciprofloxacin-resistant mutants of four clinical isolates of Pseudomonas...
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