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Article

Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish.

Nature communications - 10 Nov 2017

Lagendijk Anne Karine, Gomez Guillermo A, Baek Sungmin, Hesselson Daniel, Hughes William E, Paterson Scott, Conway Daniel E, Belting Heinz-Georg, Affolter Markus, Smith Kelly A, Schwartz Martin A, Yap Alpha S, Hogan Benjamin M

Abstract excerpt

Forces play diverse roles in vascular development, homeostasis and disease. VE-cadherin at endothelial cell-cell junctions links the contractile acto-myosin cytoskeletons of adjacent cells, serving as a tension-transducer. To explore tensile changes across VE-cadherin in live zebrafish, we tailored an optical biosensor approach, originally established in vitro. We validate localization and function of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29123087
DOI: 10.1038/s41467-017-01325-6
PMCID: PMC5680264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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