Article
Food intake and interdigestive gastrointestinal motility in ghrelin receptor mutant rats.
Journal of gastroenterology - 1 Apr 2011
Bülbül Mehmet, Babygirija Reji, Zheng Jun, Ludwig Kirk, Xu Haiyan, Lazar Jozef, Takahashi Toku
Abstract excerpt
BACKGROUND: Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR). Ghrelin regulates feeding activity and interdigestive contractions of the stomach in rodents. To investigate the role of endogenous ghrelin in the digestive system, we have developed GHSR-mutant rats, named FHH-Ghsr(m1Mcwi), using the Fawn-Hooded Hypertensive (FHH) parental strain. METHODS: N-ethyl-N-nitrosourea...
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