Article

Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases

2021-09-02

Abstract excerpt

<title>Abstract</title> <p>BackgroundThe interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its effects. Using N-ethyl-N-nitrosourea mutagenesis we found a mouse with an activating mutation in oligoadenylate synthetase 2 ( Oas2 ), a sensor of viral double stranded RNA, that resulted in an interferon response and preven...

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Literature Corpus work: ae53f24d-ee1e-5ce3-8169-670c2615fbb1
DOI: 10.21203/rs.3.rs-842107/v1

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