Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

Abstract excerpt

The 2',5'-oligoadenylate (2-5A) synthetase (OAS)-RNase L system is an IFN-induced antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS. Although all three enzymatically active OAS proteins in humans--OAS1, OAS2, and OAS3--synthesize 2-5A upon binding dsRNA, it is unclear which are responsible for RNase L activation during viral infection. We used clustered regularly interspaced short...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to interferon and immune responses
• Share to RNA regulation and disease
• Share to Viral Infections and Immunology Research