Article
The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Mar 2018
Piel J H, Lett T A, Wackerhagen C, Plichta M M, Mohnke S, Grimm O, Romanczuk-Seiferth N, Degenhardt F, Tost H, Witt S, Nöthen M, Rietschel M, Heinz A, Meyer-Lindenberg A, Walter H, Erk S
Abstract excerpt
Major depressive disorder (MDD) is characterized by low mood for at least two weeks. Impaired emotion regulation has been suggested to be the consequence of dysfunctional serotonergic regulation of limbic and prefrontal regions, especially the amygdala, the anterior cingulate cortex (ACC) and the prefrontal cortex (PFC). The impact of genetic variation on brain function can be investigated with intermediate...
Topics
- Adolescent
- Adult
- Amygdala
- Brain
- Cohort Studies
- Female
- Genotype
- Gyrus Cinguli
- Habituation, Psychophysiologic
- Healthy Volunteers