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Modulation of amygdala response and connectivity in depression by serotonin transporter polymorphism and diagnosis.

Journal of affective disorders - 15 Aug 2013

Costafreda Sergi G, McCann Peter, Saker Pascal, Cole James H, Cohen-Woods Sarah, Farmer Anne E, Aitchison Katherine J, McGuffin Peter, Fu Cynthia H Y

Abstract excerpt

BACKGROUND: Polymorphisms in the serotonin transporter gene (5-HTTLPR) modulate amygdala activity in healthy individuals. Increased responses to negative stimuli in carriers of low transcription alleles have been proposed to contribute to the pathogenesis of depression. We sought to investigate the effects of genotype as well as diagnosis in patients with depression. METHODS: Subjects with recurrent depression...

Topics

Adult
Amygdala
Case-Control Studies
Depression
Female
Genotype
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Serotonin Plasma Membrane Transport Proteins

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Identifiers

PMID: 23643106
DOI: 10.1016/j.jad.2013.02.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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