Article
Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.
Nature neuroscience - 1 Sept 2014
Nikolova Yuliya S, Koenen Karestan C, Galea Sandro, Wang Chiou-Miin, Seney Marianne L, Sibille Etienne, Williamson Douglas E, Hariri Ahmad R
Abstract excerpt
We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the...
Topics
- Adolescent
- Amygdala
- Child
- DNA Methylation
- Epigenesis, Genetic
- Female
- Genotype
- Humans
- Linear Models
- Magnetic Resonance Imaging
- Male
- Models, Neurological
- Predictive Value of Tests
- Promoter Regions, Genetic