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Article

Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression.

BMC psychiatry - 4 Sept 2018

Lam Dilys, Ancelin Marie-Laure, Ritchie Karen, Freak-Poli Rosanne, Saffery Richard, Ryan Joanne

Abstract excerpt

BACKGROUND: Disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received much attention in this regard. Most studies have focused on the polymorphic 5-HTTLPR upstream repeat, or DNA methylation at the promoter CpG island. Few studies have explored the influence of genetic variation across the gene on...

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Identifiers

PMID: 30180828
DOI: 10.1186/s12888-018-1850-4
PMCID: PMC6122720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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