Article
Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression.
BMC psychiatry - 4 Sept 2018
Lam Dilys, Ancelin Marie-Laure, Ritchie Karen, Freak-Poli Rosanne, Saffery Richard, Ryan Joanne
Abstract excerpt
BACKGROUND: Disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received much attention in this regard. Most studies have focused on the polymorphic 5-HTTLPR upstream repeat, or DNA met...
Topics
- Age Factors
- Aged
- Aged, 80 and over
- DNA Methylation
- Depressive Disorder, Major
- Female
- Genetic Association Studies
- Genotype
- Humans
- Male
- Promoter Regions, Genetic
- Random Allocation
- Self Report
- Serotonin Plasma Membrane Transport Proteins