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Article

Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.

Molecular and cellular endocrinology - 15 Jul 2018

Wijayarathna Rukmali, de Kretser David M, Meinhardt Andreas, Middendorff Ralf, Ludlow Helen, Groome Nigel P, Loveland Kate A, Hedger Mark P

Abstract excerpt

Regionalised interaction of the activins, follistatin and inhibin was investigated in the male reproductive tract of mice lacking the inhibin α-subunit (Inha-/-). Serum and intratesticular activin B, although not activin A and follistatin, were increased in Inha-/- mice at 25 days of age, but all three proteins were elevated at 56 days. None of these proteins were altered within the epididymis and vas deferens at...

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Identifiers

PMID: 29111388
DOI: 10.1016/j.mce.2017.10.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.PMID 29111388Read ↗

Testicular Somatic Cells, not Gonocytes, Are the Major Source of Functional Activin A during Testis MorphogenesisSemantic proximity Read ↗

Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction.Semantic proximity Read ↗

Activin A Balances Sertoli and Germ Cell Proliferation in the Fetal Mouse TestisSemantic proximity Read ↗

Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.Semantic proximity Read ↗

Activins Are Critical Modulators of Growth and SurvivalSemantic proximity Read ↗

Normal reproductive function in InhBP/p120-deficient mice.Semantic proximity Read ↗

Inhibin-A Antagonizes TGFβ2 Signaling by Down-Regulating Cell Surface Expression of the TGFβ Coreceptor BetaglycanSemantic proximity Read ↗

Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice.Semantic proximity Read ↗

GDF9 modulates the reproductive and tumor phenotype of female inha-null mice.Semantic proximity Read ↗

Action Mechanism of Inhibin α-Subunit on the Development of Sertoli Cells and First Wave of Spermatogenesis in MiceSemantic proximity Read ↗

Loss of Inhibin Advances Follicle Activation and Female Puberty Onset but Blocks Oocyte Maturation in ZebrafishSemantic proximity Read ↗

Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.Semantic proximity Read ↗

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