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Article

Testicular Somatic Cells, not Gonocytes, Are the Major Source of Functional Activin A during Testis Morphogenesis

27 Sept 2011

Abstract excerpt

Proper development of the seminiferous tubules (or testis cords in embryos) is critical for male fertility. Sertoli cells, somatic components of the seminiferous tubules, serve as nurse cells to the male germline, and thus their numbers decide the quantity of sperm output in adulthood. We previously identified activin A, the protein product of the activin βA (Inhba) gene, as a key regulator of murine Sertoli cell...

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PMID: 21952240
DOI: 10.1210/en.2011-1288

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Testicular Somatic Cells, not Gonocytes, Are the Major Source of Functional Activin A during Testis MorphogenesisPMID 21952240Read ↗

Activin A Balances Sertoli and Germ Cell Proliferation in the Fetal Mouse TestisSemantic proximity Read ↗

Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion.Semantic proximity Read ↗

Spermatogonial fate in mice with increased activin A bioactivity and testicular somatic cell tumoursSemantic proximity Read ↗

RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell nicheSemantic proximity Read ↗

Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin BSemantic proximity Read ↗

Cyclin A2 is essential for mouse gonocyte maturation.Semantic proximity Read ↗

TAF4b is Required for Mouse Spermatogonial Stem Cell DevelopmentSemantic proximity Read ↗

Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cellsSemantic proximity Read ↗

Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice.Semantic proximity Read ↗

Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesisSemantic proximity Read ↗

Mixed Signals: Development of the TestisSemantic proximity Read ↗

All in the family: TGF-β family action in testis developmentSemantic proximity Read ↗

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