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Article

Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.

Molecular and cellular endocrinology - 6 Nov 2008

Nagaraja Ankur K, Agno Julio E, Kumar T Rajendra, Matzuk Martin M

Abstract excerpt

The inhibins are secreted alpha:beta heterodimers of the TGF-beta superfamily that are mainly synthesized in Sertoli cells and granulosa cells, and are critical regulators of testicular and ovarian development and function. Mice homozygous for a targeted deletion of the inhibin alpha subunit gene (Inha(-/-)) develop sex cord-stromal tumors in a gonadotropin-dependent manner. Here, we determine the contribution of...

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Source

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Identifiers

PMID: 18657590
DOI: 10.1016/j.mce.2008.06.019
PMCID: PMC2743404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.PMID 18657590Read ↗

Genetic Removal of Smad3 from Inhibin-Null Mice Attenuates Tumor Progression by Uncoupling Extracellular Mitogenic Signals from the Cell Cycle MachinerySemantic proximity Read ↗

Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction.Semantic proximity Read ↗

GDF9 modulates the reproductive and tumor phenotype of female inha-null mice.Semantic proximity Read ↗

Role of androgens in testicular tumor development in inhibin-deficient mice.Semantic proximity Read ↗

Normal reproductive function in InhBP/p120-deficient mice.Semantic proximity Read ↗

Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.Semantic proximity Read ↗

Cyclin D2 and p27 Are Tissue-Specific Regulators of Tumorigenesis in Inhibin α Knockout MiceSemantic proximity Read ↗

Genetic variation in the inhibin pathway and risk of testicular germ cell tumors.Semantic proximity Read ↗

Inhibin-A Antagonizes TGFβ2 Signaling by Down-Regulating Cell Surface Expression of the TGFβ Coreceptor BetaglycanSemantic proximity Read ↗

Action Mechanism of Inhibin α-Subunit on the Development of Sertoli Cells and First Wave of Spermatogenesis in MiceSemantic proximity Read ↗

Loss of Inhibin Advances Follicle Activation and Female Puberty Onset but Blocks Oocyte Maturation in ZebrafishSemantic proximity Read ↗

Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice.Semantic proximity Read ↗

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