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Article

Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction.

PloS one - 27 Jul 2010

Nalam Roopa L, Andreu-Vieyra Claudia, Matzuk Martin M

Abstract excerpt

Sertoli cells, the support cells of mammalian spermatogenesis, are regulated by a number of nuclear factors and express retinoblastoma (RB) tumor suppressor protein. We hypothesized that RB is an important mediator of Sertoli cell tumorigenesis in inhibin alpha knockout (Inha KO) mice. In our previous mouse studies, we found that conditional knockout (cKO) of Rb in Sertoli cells caused progressive Sertoli cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20676395
DOI: 10.1371/journal.pone.0011797
PMCID: PMC2910728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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