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Article

Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.

Molecular and cellular biology - 1 Jun 2003

Beuschlein Felix, Looyenga Brendan D, Bleasdale Stephanie E, Mutch Chris, Bavers David L, Parlow Albert F, Nilson John H, Hammer Gary D

Abstract excerpt

Inhibin and activin are members of the transforming growth factor beta (TGF-beta) family of ligands produced and secreted primarily by the gonads and adrenals. Inhibin-null (INH(-/-)) mice develop gonadal tumors and-when gonadectomized-adrenocortical carcinoma. The mechanisms leading to adrenal t...

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Identifiers

PMID: 12748296
DOI: 10.1128/MCB.23.11.3951-3964.2003
PMCID: PMC155220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12748296-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.PMID 12748296Read ↗

Inhibin-A Antagonizes TGFβ2 Signaling by Down-Regulating Cell Surface Expression of the TGFβ Coreceptor BetaglycanSemantic proximity Read ↗

Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.Semantic proximity Read ↗

Origin and Identity of Adrenocortical Tumors in Inhibin Knockout Mice: Implications for Cellular Plasticity in the Adrenal CortexSemantic proximity Read ↗

Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice.Semantic proximity Read ↗

Genetic Removal of Smad3 from Inhibin-Null Mice Attenuates Tumor Progression by Uncoupling Extracellular Mitogenic Signals from the Cell Cycle MachinerySemantic proximity Read ↗

GDF9 modulates the reproductive and tumor phenotype of female inha-null mice.Semantic proximity Read ↗

Role of androgens in testicular tumor development in inhibin-deficient mice.Semantic proximity Read ↗

Activins Are Critical Modulators of Growth and SurvivalSemantic proximity Read ↗

Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.Semantic proximity Read ↗

Normal reproductive function in InhBP/p120-deficient mice.Semantic proximity Read ↗

Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction.Semantic proximity Read ↗

Cyclin D2 and p27 Are Tissue-Specific Regulators of Tumorigenesis in Inhibin α Knockout MiceSemantic proximity Read ↗

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