Article
The Red Queen model of recombination hot-spot evolution: a theoretical investigation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Dec 2017
Latrille Thibault, Duret Laurent, Lartillot Nicolas
Abstract excerpt
In humans and many other species, recombination events cluster in narrow and short-lived hot spots distributed across the genome, whose location is determined by the Zn-finger protein PRDM9. To explain these fast evolutionary dynamics, an intra-genomic Red Queen model has been proposed, based on the interplay between two antagonistic forces: biased gene conversion, mediated by double-strand breaks, resulting in...
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