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Article

Common Missense Variant of SCN9A Gene Is Associated with Pain Intensity in Patients with Chronic Pain from Disc Herniation.

Pain medicine (Malden, Mass.) - 1 May 2018

Kurzawski Mateusz, Rut Marcin, Dziedziejko Violetta, Safranow Krzysztof, Machoy-Mokrzynska Anna, Drozdzik Marek, Bialecka Monika

Abstract excerpt

Objective: Lumbar intervertebral disk herniation (LDH) is considered one of the major risk factors for lower back pain, mainly caused by irritation of a spinal nerve or its root. One of the genes related to pain perception is SCN9A, which encodes the voltage gated sodium channel NaV1.7, a key molecule involved in peripheral pain processing. It had been presented before that a common polymorphism within SCN9A...

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Source

Identifiers

PMID: 29106681
DOI: 10.1093/pm/pnx261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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