Article
The non-synonymous SNP, R1150W, in SCN9A is not associated with chronic widespread pain susceptibility.
Molecular pain - 24 Sept 2012
Holliday Kate L, Thomson Wendy, Neogi Tuhina, Felson David T, Wang Ke, Wu Frederick C, Huhtaniemi Ilpo T, Bartfai Gyorgy, Casanueva Felipe, Forti Gianni, Kula Krzysztof, Punab Margus, Vanderschueren Dirk, Macfarlane Gary J, Horan Michael A, Ollier William, Payton Antony, Pendleton Neil, McBeth John
Abstract excerpt
BACKGROUND: Mutations in SCN9A, encoding the alpha subunit of the voltage-gated sodium channel (Nav1.7), have caused severe pain disorders and congenital insensitivity to pain. The aim of this study was to validate the previously reported association between a common non-synonymous polymorphism (R1150W, rs6746030) in SCN9A and chronic widespread pain (CWP), in independent population-based cohorts. FINDINGS:...
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