Article
Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Jul 2012
Olsen Maria Belland, Jacobsen Line Melå, Schistad Elina Iordanova, Pedersen Linda Margareth, Rygh Lars Jørgen, Røe Cecilie, Gjerstad Johannes
Abstract excerpt
Earlier studies have shown that the single nucleotide polymorphism (SNP) A118G (rs1799971) in the opioid receptor mu 1 (OPRM1) gene may affect pain sensitivity. In the present study we investigated whether the A118G SNP could predict clinical outcome regarding progression of pain intensity and disability in patients with low back pain and sciatica after lumbar disc herniation. Patients (n = 258) with lumbar disc...
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