Article
A variant in the SCN10A enhancer may affect human mechanical pain sensitivity.
Molecular pain - 1 Jan 2000
Duan Guangyou, Sun Jiaoli, Li Ningbo, Zheng Hua, Guo Shanna, Zhang Yuhao, Wang Qingli, Ying Ying, Zhang Mi, Huang Penghao, Zhang Xianwei
Abstract excerpt
Expression of Nav1.8, encoded by SCN10A, can affect pain transmission and thus mediate the human pain phenotype. In the current study, we assessed whether the variant rs6801957, located in the SCN10A enhancer region, may have the potential to affect human pain. Through dual-luciferase reporter assays in 293T cells, we found that the SCN10A enhancer A (Enh-A) increased the activity of the SCN10A promoter (...
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