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Article

Variants of ACAN are associated with severity of lumbar disc herniation in patients with chronic low back pain.

PloS one - 1 Jan 2017

Perera Romain Shanil, Dissanayake Poruwalage Harsha, Senarath Upul, Wijayaratne Lalith Sirimevan, Karunanayake Aranjan Lional, Dissanayake Vajira Harshadeva Weerabaddana

Abstract excerpt

INTRODUCTION: Disc herniation is a complex spinal disorder associated with disability and high healthcare cost. Lumbar disc herniation is strongly associated with disc degeneration. Candidate genes of the aggrecan metabolic pathway may associate with the severity of lumbar disc herniation. OBJECTIVES: This study evaluated the association of single nucleotide variants (SNVs) of the candidate genes of the aggrecan...

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Share to Aggrecans
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intervertebral Disc Degeneration

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Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 28742099
DOI: 10.1371/journal.pone.0181580
PMCID: PMC5524386

Genes

ACAN
ADAMTS4
ADAMTS5
MMP3
TIMP1
TIMP2
TIMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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