Article
SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients.
Medicine - 1 Sept 2017
Sun Jiaoli, Duan Guangyou, Li Ningbo, Guo Shanna, Zhang Yuhao, Ying Ying, Zhang Mi, Wang Qingli, Liu Jing Yu, Zhang Xianwei
Abstract excerpt
Nav1.9, encoded by sodium voltage-gated channel alpha subunit 11 (SCN11A), is one of the main sodium channels involved in pain transmission. Dysfunction of Nav1.9 alters pain sensitivity, resulting in insensitivity to pain or familial episodic pain. Our purpose was to explore the effects of SCN11A single-nucleotide polymorphisms (SNPs) on postoperative pain sensitivity in Chinese Han female patients after...
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