Article
Mutation Spectrum Induced by 8-Bromoguanine, a Base Damaged by Reactive Brominating Species, in Human Cells.
Oxidative medicine and cellular longevity - 1 Jan 2017
Shinmura Kazuya, Kato Hisami, Goto Masanori, Tao Hong, Inoue Yusuke, Nakamura Satoki, Yoshida Haruki, Tsuzaki Emi, Sugimura Haruhiko
Abstract excerpt
To date, the types of mutations caused by 8-bromoguanine (8BrG), a major base lesion induced by reactive brominating species during inflammation, in human cells and the 8BrG repair system remain largely unknown. In this study, we performed a supF forward mutation assay using a shuttle vector plasmid containing a single 8BrG in three kinds of human cell lines and revealed that 8BrG in DNA predominantly induces a...
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