Article
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.
DNA repair - 2 Jan 2005
Zhang Qiu-Mei, Yonekura Shin-Ichiro, Takao Masashi, Yasui Akira, Sugiyama Hiroshi, Yonei Shuji
Abstract excerpt
Bacteria and eukaryotes possess redundant activities that recognize and remove oxidatively damaged bases from DNA through base excision repair. DNA glycosylases excise damaged bases to initiate the base excision repair pathway. hOgg1 and hNTH1, homologues of E. coli MutM and Nth, respectively, ha...
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