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Article

Chromatin Conformation Links Distal Target Genes to CKD Loci.

Journal of the American Society of Nephrology : JASN - 1 Feb 2018

Brandt Maarten M, Meddens Claartje A, Louzao-Martinez Laura, van den Dungen Noortje A M, Lansu Nico R, Nieuwenhuis Edward E S, Duncker Dirk J, Verhaar Marianne C, Joles Jaap A, Mokry Michal, Cheng Caroline

Abstract excerpt

Genome-wide association studies (GWASs) have identified many genetic risk factors for CKD. However, linking common variants to genes that are causal for CKD etiology remains challenging. By adapting self-transcribing active regulatory region sequencing, we evaluated the effect of genetic variation on DNA regulatory elements (DREs). Variants in linkage with the CKD-associated single-nucleotide polymorphism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Endothelial Cells

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Share to Renal Insufficiency, Chronic

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Identifiers

PMID: 29093029
DOI: 10.1681/ASN.2016080875
PMCID: PMC5791087

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