Article
Chromatin State Maps of Blood Pressure-Relevant Renal Segments Reveal Potential Regulatory Role for SNPs.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2025
Ray Atrayee, Yang Chun, Stelloh Cary, Tutaj Monika, Liu Pengyuan, Liu Yong, Qiu Qiongzi, Auer Paul L, Lin Chien-Wei, Widlansky Michael E, Geurts Aron M, Cowley Allen W, Liang Mingyu, Kwitek Anne E, Greene Andrew S, Rao Sridhar
Abstract excerpt
BACKGROUND: Hypertension or elevated blood pressure (BP) is a worldwide clinical challenge and the leading primary risk factor for kidney dysfunctions, heart failure, and cerebrovascular disease. The kidney is a central regulator of BP by maintaining sodium-water balance. Multiple genome-wide association studies revealed that BP is a heritable quantitative trait, modulated by several genetic, epigenetic, and...
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