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Article

Complexities of Understanding Function from CKD-Associated DNA Variants.

Clinical journal of the American Society of Nephrology : CJASN - 1 Jul 2020

Lin Jennie, Susztak Katalin

Abstract excerpt

Genome-wide association studies (GWASs) have facilitated the unbiased discovery of hundreds of genomic loci associated with CKD and kidney function. The vast majority of disease-associated DNA variants are noncoding. Those that are causal in CKD pathogenesis likely modulate transcription of target genes in a cell type-specific manner. To gain novel biological insights into mechanisms driving the development of...

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Identifiers

PMID: 32513823
DOI: 10.2215/CJN.15771219
PMCID: PMC7341770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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