Article
Urinary bladder hypertrophy characteristic of male ROMK Bartter's mice does not occur in female mice.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Mar 2018
Kim Jun-Mo, Xu Shuhua, Guo Xiaoyun, Hu Haiyan, Dong Ke, Wang Tong
Abstract excerpt
The renal outer medullary potassium channel (ROMK; Kir1.1) plays an important role in Na+ and K+ homeostasis. ROMK knockout (KO) mice show a similar phenotype to Bartter's syndrome of salt wasting and dehydration due to reduced Na-2Cl-K-cotransporter activity but not in ROMK1 KO mice. ROMK KO mice also show hydronephrosis; however, the mechanism of this phenotype has not been understood. We have previously...
Topics
- Animals
- Bartter Syndrome
- Disease Models, Animal
- Female
- Genetic Predisposition to Disease
- Hydronephrosis
- Hypertrophy
- Male
- Mice, Knockout
- Muscle, Smooth
- Organ Size