Article
Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2013
Zhou Xiaoyan, Zhang Zuo, Shin Myung Kyun, Horwitz Sarah Beth, Levorse John M, Zhu Lei, Sharif-Rodriguez Wanda, Streltsov Denis Y, Dajee Maya, Hernandez Melba, Pan Yi, Urosevic-Price Olga, Wang Li, Forrest Gail, Szeto Daphne, Zhu Yonghua, Cui Yan, Michael Bindhu, Balogh Leslie Ann, Welling Paul A, Wade James B, Roy Sophie, Sullivan Kathleen A
Abstract excerpt
The renal outer medullary potassium channel (ROMK, KCNJ1) mediates potassium recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Human genetic studies indicate that ROMK homozygous loss-of-function mutations cause type II Bartter syndrome, featuring polyuria, renal salt wasting, and hypotension;...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.