Article
The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK.
Scientific reports - 20 Dec 2019
Schiano Guglielmo, Glaudemans Bob, Olinger Eric, Goelz Nadine, Müller Michael, Loffing-Cueni Dominique, Deschenes Georges, Loffing Johannes, Devuyst Olivier
Abstract excerpt
Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the potassium channel ROMK in TAL cells. Common variants in KCNJ1, the gene encoding ROMK, are associated with urinary levels of uromodulin in population studies. Here, we investigated the functional link between ROMK and uromodulin in Kcnj1...
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