Article
Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2008
Yan Qingshang, Yang Xinbo, Cantone Alessandra, Giebisch Gerhard, Hebert Steven, Wang Tong
Abstract excerpt
ROMK null mice with a high survival rate and varying severity of hydronephrosis provide a good model to study type II Bartter syndrome pathophysiology (26). During the development of such a colony, we found that more male than female null mice survived, 58.7% vs. 33.3%. To investigate the possible mechanism of this difference, we compared the survival rates, renal functions, degree of hydronephrosis, as well as...
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