Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice.

The Journal of pathology - 1 Aug 2012

Wilkinson Lorine, Kurniawan Nyoman D, Phua Yu Leng, Nguyen Michael J, Li Joan, Galloway Graham J, Hashitani Hikaru, Lang Richard J, Little Melissa H

Abstract excerpt

Crim1 hypomorphic (Crim1(KST264/KST264)) mice display progressive renal disease characterized by glomerular defects, leaky peritubular vasculature, and progressive interstitial fibrosis. Here we show that 27% of these mice also present with hydronephrosis, suggesting obstructive nephropathy. Dynamic magnetic resonance imaging using Magnevist showed fast development of hypo-intense signal in the kidneys of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dextrans
Share to Kidney Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Medulla

Share to Magnetic Resonance Imaging

Share to Models, Animal

Share to Muscle Contraction

Share to Myocytes, Smooth Muscle

Share to Rhodamines

Source

Identifiers

PMID: 22488641
DOI: 10.1002/path.4036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice.PMID 22488641Read ↗

Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation.Semantic proximity Read ↗

Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins.Semantic proximity Read ↗

Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.Semantic proximity Read ↗

Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis.Semantic proximity Read ↗

Identification of a Unique Transgenic Mouse Line That Develops Megabladder, Obstructive Uropathy, and Renal DysfunctionSemantic proximity Read ↗

Plumbing in the embryo: developmental defects of the urinary tractsSemantic proximity Read ↗

Developmental Renal Glomerular Defects at the Origin of Glomerulocystic DiseaseSemantic proximity Read ↗

Urinary bladder hypertrophy characteristic of male ROMK Bartter's mice does not occur in female mice.Semantic proximity Read ↗

Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human SystemSemantic proximity Read ↗

Visceral myopathy: clinical syndromes, genetics, pathophysiology, and fall of the cytoskeleton.Semantic proximity Read ↗

Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.Semantic proximity Read ↗

Uroplakins: new molecular players in the biology of urinary tract malformations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.