Article
Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice.
The Journal of biological chemistry - 4 Oct 2002
Lu Ming, Wang Tong, Yan Qingshang, Yang Xinbo, Dong Ke, Knepper Mark A, Wang WenHui, Giebisch Gerhard, Shull Gary E, Hebert Steven C
Abstract excerpt
The ROMK (Kir1.1; Kcnj1) gene is believed to encode the apical small conductance K(+) channels (SK) of the thick ascending limb (TAL) and cortical collecting duct (CCD). Loss-of-function mutations in the human ROMK gene cause Bartter's syndrome with renal Na(+) wasting, consistent with the role of this channel in apical K(+) recycling in the TAL that is crucial for NaCl reabsorption. However, the mechanism of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.