Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster.

PloS one - 1 Jan 2016

Lindström Riitta, Lindholm Päivi, Kallijärvi Jukka, Palgi Mari, Saarma Mart, Heino Tapio I

Abstract excerpt

Disturbances in the homeostasis of endoplasmic reticulum (ER) referred to as ER stress is involved in a variety of human diseases. ER stress activates unfolded protein response (UPR), a cellular mechanism the purpose of which is to restore ER homeostasis. Previous studies show that Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) is an important novel component in the regulation of UPR. In vertebrates,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Chaperone BiP
Share to Endoplasmic Reticulum Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene Knockdown Techniques

Share to Genes, Insect

Share to Nerve Growth Factors

Share to RNA Splicing

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 26975047
DOI: 10.1371/journal.pone.0151550
PMCID: PMC4790953

Genes

MANF
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster.PMID 26975047Read ↗

Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes.Semantic proximity Read ↗

C. elegans MANF Homolog Is Necessary for the Protection of Dopaminergic Neurons and ER Unfolded Protein ResponseSemantic proximity Read ↗

Drosophila as a model for unfolded protein response researchSemantic proximity Read ↗

Unfolded Protein Response in Drosophila: Why Another Model Can Make It FlySemantic proximity Read ↗

The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegansSemantic proximity Read ↗

UPR Responsive Genes Manf and Xbp1 in StrokeSemantic proximity Read ↗

Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress.Semantic proximity Read ↗

ERO1A inhibition mitigates neuronal ER stress and ameliorates UBQLN2ALS phenotypes in Drosophila melanogaster.Semantic proximity Read ↗

Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.Semantic proximity Read ↗

A neuroprotective role of Ufmylation through Atg9 in the aging brain of DrosophilaSemantic proximity Read ↗

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.Semantic proximity Read ↗

ER Stress Activates the TOR Pathway through Atf6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.