Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells.

Oncotarget - 21 Mar 2025

Kazim Noor, Peng Wang, Yue Jianbo, Yen Andrew

Abstract excerpt

Retinoic acid (RA), an embryonic morphogen, is used in cancer differentiation therapy, causing extensive gene expression changes leading to cell differentiation. This study reveals that the expression of the Src-family kinase (SFK), FGR, alone can induce cell differentiation similar to RA. Traditionally, RA's mechanism involves transcriptional activation via RAR/RXR(Retinoic Acid Receptor/Retinoid X Receptor)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-ribosyl Cyclase 1
Share to Cell Differentiation
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HL-60 Cells

Share to Phosphorylation

Share to Proto-Oncogene Proteins

Share to src-Family Kinases

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 40116400
DOI: 10.18632/oncotarget.28705
PMCID: PMC11927794

Genes

FGR
CBL
CD38
LYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells.PMID 40116400Read ↗

FGR Src Family Kinase Causes Signaling and Phenotypic Shift Mimicking Retinoic Acid-Induced Differentiation of Leukemic CellsSemantic proximity Read ↗

Retinoic acid induces expression of SLP-76: expression with c-FMS enhances ERK activation and retinoic acid-induced differentiation/G0 arrest of HL-60 cells.Semantic proximity Read ↗

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemiaSemantic proximity Read ↗

The Pleiotropic Role of Retinoic Acid/Retinoic Acid Receptors Signaling: From Vitamin A Metabolism to Gene Rearrangements in Acute Promyelocytic LeukemiaSemantic proximity Read ↗

Retinoic acid-induced growth arrest and differentiation: retinoic acid up-regulates CD32 (Fc gammaRII) expression, the ectopic expression of which retards the cell cycle.Semantic proximity Read ↗

Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemiaSemantic proximity Read ↗

The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulationSemantic proximity Read ↗

Rexinoid-Triggered Differentiation and Tumor-Selective Apoptosis of Acute Myeloid Leukemia by Protein Kinase A–Mediated Desubordination of Retinoid X ReceptorSemantic proximity Read ↗

retinoic acid, bromodeoxyuridine, and the Delta 205 mutant polyoma virus middle T antigen regulate expression levels of a common ensemble of proteins associated with early stages of inducing HL-60 leukemic cell differentiation.Semantic proximity Read ↗

Mutant transcription factors and tyrosine kinases as therapeutic targets for leukemias: from acute promyelocytic leukemia to chronic myeloid leukemia and beyond.Semantic proximity Read ↗

RARG Gene Dysregulation in Acute Myeloid LeukemiaSemantic proximity Read ↗

Genome Agnostic Reprogramming of Acute Myelocytic Leukemia Hallmarks by Targeting Non-Oncogene Addictions with Azacitidine plus Pioglitazone and All-Trans Retinoic AcidSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.