Article

Computational Modeling of ATM Signaling: A Predictive Framework for Drug Repurposing in Ataxia-telangiectasia

2025-04-21

Abstract excerpt

<title>Abstract</title> <p>Ataxia-Telangiectasia (A-T) is a rare genetic disorder caused by ATM mutations, leading to impaired DNA repair, oxidative stress, and neurodegeneration. We developed a dynamic computational model of ATM-mediated signaling using ordinary differential equations in COPASI, capturing key molecular processes including DNA damage sensing, cell cycle regulation, autophagy, and oxidative stress...

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Literature Corpus work: 87b43002-1848-5d12-8e36-9c392626656b
DOI: 10.21203/rs.3.rs-6331053/v1

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