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FGR Src Family Kinase Causes Signaling and Phenotypic Shift Mimicking Retinoic Acid-Induced Differentiation of Leukemic Cells

2024-08-22

Abstract excerpt

<h4>ABSTRACT</h4> Retinoic acid (RA) is an embryonic morphogen used in cancer differentiation-therapy. It causes a plethora of changes in gene expression culminating in cell differentiation. We now find that amongst them, expression of the Src-family-kinase, FGR, by itself causes cell differentiation analogous to RA. The historically dominant/classical paradigm for RA mechanism of action is transcriptional activa...

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Literature Corpus work
d1a581e5-780c-5097-babb-668b6cdda211
DOI
10.1101/2024.08.21.608654
Open publication

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FGR Src Family Kinase Causes Signaling and Phenotypic Shift Mimicking Retinoic Acid-Induced Differentiation of Leukemic CellsDOI 10.1101/2024.08.21.608654
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