Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction

1 Jul 2020

Abstract excerpt

Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon alpha (IFNα) orchestrates antiviral responses in hepatocytes, yet mechanisms that define pathway sensitization in response to prestimulation with different IFNα doses remained unresolved. We establish, based on quantitative measurements obtained for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immune Response and Inflammation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32696599
DOI: 10.15252/msb.20198955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transductionPMID 32696599Read ↗

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α ResponseSemantic proximity Read ↗

Single-cell analysis of signalling and transcriptional responses to type I interferonsSemantic proximity Read ↗

IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling.Semantic proximity Read ↗

IFN-λ4 desensitizes the response to IFN-α treatment in chronic hepatitis C through long-term induction of USP18Semantic proximity Read ↗

Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expressionSemantic proximity Read ↗

USP18 establishes the transcriptional and anti-proliferative interferon α/β differentialSemantic proximity Read ↗

IFNβ‐dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damageSemantic proximity Read ↗

Baseline sensitivity of T cells to alpha-IFN correlates with sustained virological response to IFN-based triple therapy in HCV infection.Semantic proximity Read ↗

IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infectionSemantic proximity Read ↗

Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiencySemantic proximity Read ↗

Gene regulatory logic of the interferon-β enhancer contains multiple selectively deployed modes of transcription factor synergySemantic proximity Read ↗

Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.