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Article

H2A O-GlcNAcylation at serine 40 functions genomic protection in association with acetylated H2AZ or γH2AX.

Epigenetics & chromatin - 30 Oct 2017

Hayakawa Koji, Hirosawa Mitsuko, Tani Ruiko, Yoneda Chikako, Tanaka Satoshi, Shiota Kunio

Abstract excerpt

BACKGROUND: We have previously reported a novel O-GlcNAc modification at serine 40 (S40) of H2A (H2AS40Gc). S40-type H2A isoforms susceptible to O-GlcNAcylation are evolutionarily new and restricted to the viviparous animals; however, the biological function of H2AS40Gc is largely unknown. H2A isoforms are consisted of S40 and alanine 40 (A40) type and this residue on H2A is located in the L1 of the globular...

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Identifiers

PMID: 29084613
DOI: 10.1186/s13072-017-0157-x
PMCID: PMC5663087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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