Article
GlcNAcylation of histone H2B facilitates its monoubiquitination.
Nature - 27 Nov 2011
Fujiki Ryoji, Hashiba Waka, Sekine Hiroki, Yokoyama Atsushi, Chikanishi Toshihiro, Ito Saya, Imai Yuuki, Kim Jaehoon, He Housheng Hansen, Igarashi Katsuhide, Kanno Jun, Ohtake Fumiaki, Kitagawa Hirochika, Roeder Robert G, Brown Myles, Kato Shigeaki
Abstract excerpt
Chromatin reorganization is governed by multiple post-translational modifications of chromosomal proteins and DNA. These histone modifications are reversible, dynamic events that can regulate DNA-driven cellular processes. However, the molecular mechanisms that coordinate histone modification patterns remain largely unknown. In metazoans, reversible protein modification by O-linked N-acetylglucosamine (GlcNAc) is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.