Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Focus on histone variant H2AX: to be or not to be.

FEBS letters - 10 Sept 2010

Yuan Jingsong, Adamski Rachel, Chen Junjie

Abstract excerpt

Phosphorylation of histone variant H2AX at serine 139, named gammaH2AX, has been widely used as a sensitive marker for DNA double-strand breaks (DSBs). gammaH2AX is required for the accumulation of many DNA damage response (DDR) proteins at DSBs. Thus it is believed to be the principal signaling protein involved in DDR and to play an important role in DNA repair. However, only mild defects in DNA damage signaling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Breaks, Double-Stranded
Share to DNA Damage
Share to DNA Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histones

Share to Mammals

Share to Phosphoserine

Share to Serine

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 20493860
DOI: 10.1016/j.febslet.2010.05.021
PMCID: PMC3695482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Focus on histone variant H2AX: to be or not to be.PMID 20493860Read ↗

H2AX: the histone guardian of the genome.Semantic proximity Read ↗

Genome Instability and γH2AX.Semantic proximity Read ↗

Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing RadiationSemantic proximity Read ↗

H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer TherapySemantic proximity Read ↗

Phosphorylation of H2A.XTyr39 positively regulates DNA damage response and is linked to cancer progression.Semantic proximity Read ↗

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.Semantic proximity Read ↗

Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.Semantic proximity Read ↗

Immunofluorescence Microscopy of γH2AX and 53BP1 for Analyzing the Formation and Repair of DNA Double-strand BreaksSemantic proximity Read ↗

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.Semantic proximity Read ↗

Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage ResponseSemantic proximity Read ↗

Genomic instability in mice lacking histone H2AX.Semantic proximity Read ↗

H2AX post-translational modifications in the ionizing radiation response and homologous recombination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.