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Article

Mitochondrial Uncoupling Attenuates Age-Dependent Neurodegeneration in C. elegans.

Molecules and cells - 30 Nov 2017

Cho Injeong, Song Hyun-Ok, Cho Jeong Hoon

Abstract excerpt

The uncoupling protein 4 (ucp-4) gene is involved in age-dependent neurodegeneration in C. elegans. Therefore, we aimed to investigate the mechanism underlying the association between mitochondrial uncoupling and neurodegeneration by examining the effects of uncoupling agents and ucp-4 overexpression in C. elegans. Treatment with either DNP or CCCP improved neuronal defects in wild type during aging. Uncoupling...

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Identifiers

PMID: 29081084
DOI: 10.14348/molcells.2017.0172
PMCID: PMC5712516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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