Article
Neurosecretory control of aging in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 1999
Ailion M, Inoue T, Weaver C I, Holdcraft R W, Thomas J H
Abstract excerpt
In the nematode Caenorhabditis elegans, an insulin receptor signaling pathway regulates adult life span and developmental arrest at the dauer larval stage. Here we show that the unc-64 and unc-31 genes also function in this pathway. These two genes are involved in mediating Ca2+-regulated secretion. Mutations in unc-64 and unc-31 increase adult life span and cause constitutive dauer formation. Both phenotypes are...
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